Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study.

ABSTRACT: Glomerular filtration rate (GFR) declines with age by approx. 1 ml/min/m² per year beginning in the third decade of life. At 70 years of age > 40 ml/min/m² of GFR will be lost. Thus, factors affecting loss of GFR have significant public health implications. Furthermore, the definition of chronic kidney disease based on GFR may not be appropriate for the elderly. We analyzed factors affecting absolute and relative change of eGFR over a 5 year period in 12,381 participants of the Gutenberg Health Study. We estimated GFR at baseline and after 5 years of follow-up by two different equations. Association with the decline of estimated GFR (eGFR) was assessed by multivariable regression analysis. We confirmed a median loss of eGFR per year of approx. 1 ml/min/m².

SUBMITTER: Waas T 

PROVIDER: S-EPMC8119940 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature