Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium.

ABSTRACT: Radon is a leading cause of lung cancer in indoor public and mining workers. Inhaled radon progeny releases alpha particles, which can damage cells in the airway epithelium. The extent and complexity of cellular damage vary depending on the alpha particle's kinetic energy and cell characteristics. We developed a framework to quantitate the cellular damage on the nanometer and micrometer scales at different intensities of exposure to radon progenies Po-218 and Po-214. Energy depositions along the tracks of alpha particles that were slowing down were simulated on a nanometer scale using the Monte Carlo code Geant4-DNA. The nano-scaled track histories in a 5 μm radius and 1 μm-thick cylindrical volume were integrated into the tracking scheme of alpha trajectories in a micron-scale bronchial e

SUBMITTER: Abu Shqair A 

PROVIDER: S-EPMC8119983 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature