Cardamonin inhibits the progression of oesophageal cancer by inhibiting the PI3K/AKT signalling pathway.

ABSTRACT: Background: Oesophageal cancer is the most common malignant tumour with a poor prognosis, and the current treatment methods are limited. Therefore, identifying effective treatment methods has become a research hotspot. Cardamonin (CAR) is a natural chalcone compound and has been reported to play an anticancer role in several cancers. However, its function in oesophageal cancer and the possible underlying mechanism are still unclear. The purpose of this study was to demonstrate the anticancer effect of CAR on oesophageal cancer in vivo and in vitro and to explore the underlying mechanism. Materials and Methods: MTT, crystal violet, and colony formation assays were used to detect oesophageal cancer cell proliferation. The effects of CAR on oesophageal cancer cell

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8120183 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature