High-Throughput Absolute Quantification Sequencing Revealed Osteoporosis-Related Gut Microbiota Alterations in Han Chinese Elderly.

ABSTRACT:

Objective

Accumulative evidence suggests that gut microbiota play an important role in bone remodeling and hence bone health maintenance. This study aimed to explore the association of gut microbiota with the risk of osteoporosis and to identify potential disease-related taxa, which may be promising targets in osteoporosis prevention and treatment in the future.

Methods

Absolute quantification 16S ribosomal RNA gene sequencing was used to detect absolute and relative abundances of gut microbiota in 44 patients with osteoporosis and 64 controls. In combination with one of our previous studies, a total of 175 samples were involved in the relative abundance analysis.

Results

Compared with the controls, the patients with osteoporosis had higher absolute and relative abund

SUBMITTER: Wei M 

PROVIDER: S-EPMC8120270 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature