RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis.

ABSTRACT: Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show that RIPK3 is involved in the progression of spontaneous intestinal tumorigenesis. As a clinical correlate, reduced expression of RIPK3 is positively associated with histological grade, lymphatic metastasis and poor prognosis in CRC patients. RIPK3-deficient (Ripk3^-/- ) mice exhibit increased tumor formation in Apc^min/+ spontaneous intestinal tumorigenesis. Apc^min/+Ripk3^-/- tumors promote hyperactivation of IL-6/STAT3 signaling, which exacerbates proliferation and inhibits ap

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC8120274 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature