Blunted rest-activity rhythms link to higher body mass index and inflammatory markers in children.

ABSTRACT:

Study objectives

Disturbances of rest-activity rhythms are associated with higher body mass index (BMI) in adults. Whether such relationship exists in children is unclear. We aimed to examine cross-sectional associations of rest-activity rhythm characteristics with BMI z-score and obesity-related inflammatory markers in school-age children.

Methods

Participants included 411 healthy children (mean ± SD age 10.1 ± 1.3 years, 50.8% girls) from a Mediterranean area of Spain who wore wrist accelerometers for 7 consecutive days. Metrics of rest-activity rhythm were derived using both parametric and nonparametric approaches. Obesity-related inflammatory markers were measured in saliva (n = 121).

Results

In a multivariable-adjusted model, higher BMI z-score is associated with

SUBMITTER: Qian J 

PROVIDER: S-EPMC8120335 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature