Effects of different exercise modalities on cardiac dysfunction in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent disease. Physical exercise has been shown to alter disease progression in HFpEF. We examined cardiomyocyte Ca²⁺ homeostasis and left ventricular function in a metabolic HFpEF model in sedentary and trained rats following 8 weeks of moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT).

Methods and results

Left ventricular in vivo function (echocardiography) and cardiomyocyte Ca²⁺ transients (CaTs) (Fluo-4, confocal) were compared in ZSF-1 obese (metabolic syndrome, HFpEF) and ZSF-1 lean (control) 21- and 28-week-old rats. At 21 weeks, cardiomyocytes from HFpEF rats showed prolonged Ca²⁺ reuptake in cytosolic and nuclear

SUBMITTER: Bode D 

PROVIDER: S-EPMC8120378 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature