Longitudinal profiling of circulating miRNA during cardiac allograft rejection: a proof-of-concept study.

ABSTRACT:

Aims

Allograft rejection following heart transplantation (HTx) is a serious complication even in the era of modern immunosuppressive regimens and causes up to a third of early deaths after HTx. Allograft rejection is mediated by a cascade of immune mechanisms leading to acute cellular rejection (ACR) and/or antibody-mediated rejection (AMR). The gold standard for monitoring allograft rejection is invasive endomyocardial biopsy that exposes patients to complications. Little is known about the potential of circulating miRNAs as biomarkers to detect cardiac allograft rejection. We here present a systematic analysis of circulating miRNAs as biomarkers and predictors for allograft rejection after HTx using next-generation small RNA sequencing.

Methods and results

We used next-gen

SUBMITTER: Kennel PJ 

PROVIDER: S-EPMC8120386 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature