Diagnosing heart failure in primary care: individual patient data meta-analysis of two European prospective studies.

ABSTRACT:

Aims

Natriuretic peptides are helpful in detecting chronic heart failure (HF) in primary care; however, there are a lack of data evaluating thresholds recommended by clinical guidelines. This study assesses the diagnostic accuracy of N-terminal pro-B-type natriuretic peptide (NT-proBNP) using combined individual patient data from two studies in the UK and the Netherlands.

Methods and results

Random effects methods were used to estimate the performance characteristics of NT-proBNP thresholds recommended by the European Society of Cardiology (ESC) and the UK National Institute for Health and Care Excellence (NICE) guidelines. New onset HF was diagnosed in 313 of 1073 (29.2%) participants. Age, sex, and atrial fibrillation-adjusted NT-proBNP was a better predictor of HF with re

SUBMITTER: Roalfe AK 

PROVIDER: S-EPMC8120419 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature