Wnt/β-catenin Signaling Inhibitors suppress the Tumor-initiating properties of a CD44⁺CD133⁺ subpopulation of Caco-2 cells.

ABSTRACT: Tumor-initiating cells or cancer stem cells are a subset of cancer cells that have tumorigenic potential in human cancer. Although several markers have been proposed to distinguish tumor-initiating cells from colorectal cancer cells, little is known about how this subpopulation contributes to tumorigenesis. Here, we characterized a tumor-initiating cell subpopulation from Caco-2 colorectal cancer cells. Based on the findings that Caco-2 cell subpopulations express different cell surface markers, we were able to discriminate three main fractions, CD44^-CD133^-, CD44^-CD133⁺, and CD44⁺CD133⁺ subsets, and characterized their biochemical and tumorigenic properties. Our results show that CD44⁺CD133⁺ cells posse

SUBMITTER: Kim J 

PROVIDER: S-EPMC8120464 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature