Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.

ABSTRACT:

Background

Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown.

Objective

To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups.

Design

Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT00000611).

Setting

40 U.S. clinical centers.

Participants

9939 women aged 50 to 79 years with prior hysterectomy and known oophorectomy status.

Intervention

Conjugated equine estrogens (CEE) (0.625 mg/d) or placebo for a median of 7.2 years.

Measurements

Incidence of coronary heart disease and invasive breast cancer (the trial's 2 primary end points), all-cause m

SUBMITTER: Manson JE 

PROVIDER: S-EPMC8120507 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature