Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry.

ABSTRACT: Most of the fascinating phenomena studied in cell biology emerge from interactions among highly organized multimolecular structures embedded into complex and frequently dynamic cellular morphologies. For the exploration of such systems, computer simulation has proved to be an invaluable tool, and many researchers in this field have developed sophisticated computational models for application to specific cell biological questions. However, it is often difficult to reconcile conflicting computational results that use different approaches to describe the same phenomenon. To address this issue systematically, we have defined a series of computational test cases ranging from very simple to moderately complex, varying key features of dimensionality, reaction type, reaction speed, crowding, and c

SUBMITTER: Johnson ME 

PROVIDER: S-EPMC8120688 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature