Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma.

ABSTRACT:

Background

Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the function of DEC2 in the dormancy of salivary adenoid cystic carcinoma (SACC) in vitro and vivo.

Methods

The function of DEC2 in tumor dormancy of SACC was investigated in nude mice by establishing primary and lung metastasis model. Meanwhile, the interaction between hypoxia and SACC dormancy and the role of DEC2 were demonstrated through CoCl₂ induced hypoxia-mimicking microenvironments. Furthermore, the expression of DEC2 was detected by immunohistochemical staining in primary SACC samples with and without recurrence.

Results

In the primary SA

SUBMITTER: Yang X 

PROVIDER: S-EPMC8120837 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature