A Neural Network Approach to Identify Glioblastoma Progression Phenotype from Multimodal MRI.

ABSTRACT: The phenotypes of glioblastoma (GBM) progression after treatment are heterogeneous in both imaging and clinical prognosis. This study aims to apply radiomics and neural network analysis to preoperative multimodal MRI data to characterize tumor progression phenotypes. We retrospectively reviewed 41 patients with newly diagnosed cerebral GBM from 2009-2016 who comprised the machine learning training group, and prospectively included 18 patients from 2017-2018 for data validation. Preoperative MRI examinations included structural MRI, diffusion tensor imaging, and perfusion MRI. Tumor progression patterns were categorized as diffuse or localized. A supervised machine learning model and neural network-based models (VGG16 and ResNet50) were used to establish the prediction model of the pattern

SUBMITTER: Yan JL 

PROVIDER: S-EPMC8121245 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature