Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis.

ABSTRACT: Sepsis induces significant immune dysregulation characterized by lymphocyte apoptosis and alterations in the cytokine milieu. Because cancer patients exhibit a 10-fold greater risk of developing sepsis compared with the general population, we aimed to understand how pre-existing malignancy alters sepsis-induced immune dysregulation. To address this question, we assessed the impact of tumor-specific CD8⁺ T cells on the immune response in a mouse model of cecal ligation and puncture (CLP)-induced sepsis. Tumor-bearing animals containing Thy1.1⁺ tumor-specific CD8⁺ T cells were subjected to CLP, and groups of animals received anti-Thy1.1 mAb to deplete tumor-specific CD8⁺ T cells or isotype control. Results indicated that depleting tumor-specific T

SUBMITTER: Chen CW 

PROVIDER: S-EPMC8121248 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature