Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjogren's syndrome.

ABSTRACT:

Objectives

To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-fluorodeoxyglucose (18F-FDG; glucose uptake marker), to assess protein synthesis and inflammation, respectively; multiparametric MRI evaluated salivary gland structural and physiological changes.

Methods

In this imaging/clinical/histology comparative study (GSK study 203818; NCT02899377) patients with pSS and age- and sex-matched healthy volunteers underwent MRI of the salivary glands and 11C-MET PET-CT. Patients also underwent 18F-FDG PET-CT and labial salivary gland biopsies. Clinical and biomarker assessments were performed. Pr

SUBMITTER: Jimenez-Royo P 

PROVIDER: S-EPMC8121449 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature