IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii.

ABSTRACT: IL-33 is an alarmin required for resistance to the parasite Toxoplasma gondii, but its role in innate resistance to this organism is unclear. Infection with T. gondii promotes increased stromal cell expression of IL-33, and levels of parasite replication correlate with release of IL-33 in affected tissues. In response to infection, a subset of innate lymphoid cells (ILC) emerges composed of IL-33R⁺ NK cells and ILC1s. In Rag1^-/-mice, where NK cells and ILC1 production of IFN-γ mediate innate resistance to T. gondii, the loss of the IL-33R resulted in reduced ILC responses and increased parasite replication. Furthermore, administration of IL-33 to Rag1^-/- mice resulted in a marked decrease in parasite burden, increased prod

SUBMITTER: Clark JT 

PROVIDER: S-EPMC8121546 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature