Receptor-mediated mitophagy regulates EPO production and protects against renal anemia.

ABSTRACT: Erythropoietin (EPO) drives erythropoiesis and is secreted mainly by the kidney upon hypoxic or anemic stress. The paucity of EPO production in renal EPO-producing cells (REPs) causes renal anemia, one of the most common complications of chronic nephropathies. Although mitochondrial dysfunction is commonly observed in several renal and hematopoietic disorders, the mechanism by which mitochondrial quality control impacts renal anemia remains elusive. In this study, we showed that FUNDC1, a mitophagy receptor, plays a critical role in EPO-driven erythropoiesis induced by stresses. Mechanistically, EPO production is impaired in REPs in Fundc1^-/- mice upon stresses, and the impairment is caused by the accumulation of damaged mitochondria, which consequently leads to the eleva

SUBMITTER: Geng G 

PROVIDER: S-EPMC8121547 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature