GABA_B receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.

ABSTRACT: The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca²⁺ channels (Cav2.3) and auxiliary GABA_B receptor (GBR) subunits, the K⁺-channel tetramerization domain-containing proteins (KCTDs). Activation of GBRs facilitates or inhibits transmitter release from MHb terminals depending on the IPN subnucleus, but the role of KCTDs is unknown. We therefore examined the localization and function of Cav2.3, GBRs, and KCTDs in this pathway in mice. We show in heterologous cells that KCTD8 and KCTD12b directly bind to Cav2.3 and that KCTD8 potentiates Cav2.3 currents in the absence of GBRs. In the rostral IPN, KCTD8, KCTD12b, and Cav2.3 co-localize at the presynaptic a

SUBMITTER: Bhandari P 

PROVIDER: S-EPMC8121548 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature