Impact of Albendazole on Cytokine and Chemokine Response Profiles in Echinococcus multilocularis-Inoculated Mice.

ABSTRACT:

Objective

Alveolar echinococcosis (AE) is a zoonosis caused by the larval stage of the metacestode Echinococcosis multilocularis with a tumor-like behavior in the targeted organ, especially in the liver. Surgery with albendazole is first-line modality for AE. Drug discontinuation is usually based upon the parasitic viability shown by the positron emission tomography (PET) scan. However, as a demanding and expensive method, it is not widely practiced in majority of the endemic regions. Further understanding on the cytokine and chemokine response profiles in AE patients may provide an interesting insight for potential markers in viability assessment.

Methods

Mice were inoculated with Echinococcus multilocularis intrahepatically to develop the hepatic AE murine mo

SUBMITTER: Wu J 

PROVIDER: S-EPMC8121589 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature