Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery.

ABSTRACT:

Background

Modern anesthesia strives to offer personalized concepts to meet the patient's individual needs in sight of clinical outcome. Still, little is known about the impact of anesthesia on the plasma metabolome, although many metabolites have been shown to modulate the function of various immune cells, making it particularly interesting in the context of oncological surgery. In this study longitudinal dynamics in the plasma metabolome during general anesthesia in patients undergoing pancreatic surgery were analyzed.

Materials and methods

Prospective, observational study with 10 patients diagnosed with pancreatic (pre-) malignancy and subjected to elective resection surgery under general anesthesia. Plasma metabolites (n = 630) were quantified at eight consecutive

SUBMITTER: Mock-Ohnesorge J 

PROVIDER: S-EPMC8121611 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature