Association between miRNA signatures in serum samples from epidermal growth factor inhibitor treated patients and skin toxicity.

ABSTRACT:

Objective

Epidermal growth factor receptor inhibitors (EGFRI) are used as targeted cancer therapy. On average 70% of patients treated with EGFRIs suffer from skin toxicity. Studies showed a correlation between overall survival and the appearance of a skin rash, which is used as a biomarker for therapy efficacy. Micro RNAs (miRNA) as tumor or resistance biomarkers for cancer therapy are also highly investigated. In our study, we searched for associations of miRNA expression profiles in serum, with the severity of skin rash, in order to identify tentative therapy predictive biomarkers.

Materials and methods

Five candidate miRNAs were selected, based on an earlier in vitro next-generation-sequencing-experiment and after literature search. MiR-21, miR-31, miR-17, miR-106b

SUBMITTER: Kemski S 

PROVIDER: S-EPMC8121613 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature