Phenanthrene alters the electrical activity of atrial and ventricular myocytes of a polar fish, the Navaga cod.

ABSTRACT: Oil and gas exploration in the Arctic can result in the release of polycyclic aromatic hydrocarbons (PAHs) into relatively pristine environments. Following the recent spill of approximately 17 500 tonnes of diesel fuel in Norilsk, Russia, May 2020, our study focussed on the effects of phenanthrene, a low molecular weight PAH found in diesel and crude oil, on the isolated atrial and ventricular myocytes from the heart of the polar teleost, the Navaga cod (Eleginus nawaga). Acute exposure to phenanthrene in navaga cardiomyocytes caused significant action potential (AP) prolongation, confirming the proarrhythmic effects of this pollutant. We show AP prolongation was due to potent inhibition of the main repolarising current, I_Kr, with an IC₅₀ value of ~2 µM. We also show

SUBMITTER: Abramochkin DV 

PROVIDER: S-EPMC8121755 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature