Decreased maximal cortisol secretion rate in patients with cirrhosis: Relation to disease severity.

ABSTRACT:

Background & aims

Hepatic enzymes play a major role in the metabolic elimination of cortisol, and reduced rates of cortisol clearance have been consistently observed in patients with chronic liver disease. It is less clear whether there are concomitant abnormalities of adrenocortical function in patients with cirrhosis. In the present study, we sought to assess adrenocortical function in patients with cirrhosis using measures of free cortisol appearance and elimination rates that are independent of serum concentrations of cortisol binding proteins.

Methods

Post hoc analysis used computer-assisted numerical and modelling methods with serial total and free cortisol concentration data to obtain rates of free cortisol appearance and elimination. Rate parameters were obtai

SUBMITTER: Lovato CM 

PROVIDER: S-EPMC8121968 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature