Small Animal IMRT Using 3D-Printed Compensators.

ABSTRACT:

Purpose

Preclinical radiation replicating clinical intensity modulated radiation therapy (IMRT) techniques can provide data translatable to clinical practice. For this work, treatment plans were created for oxygen-guided dose-painting in small animals using inverse-planned IMRT. Spatially varying beam intensities were achieved using 3-dimensional (3D)-printed compensators.

Methods and materials

Optimized beam fluence from arbitrary gantry angles was determined using a verified model of the XRAD225Cx treatment beam. Compensators were 3D-printed with varied thickness to provide desired attenuation using copper/polylactic-acid. Spatial resolution capabilities were investigated using printed test-patterns. Following American Association of Physicists in Medicine TG119, a 5-beam

SUBMITTER: Redler G 

PROVIDER: S-EPMC8122034 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature