Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use.

ABSTRACT:

Rationale

Substantial variability in response to asthma treatment with inhaled corticosteroids (ICS) has been described among individuals and populations, suggesting the contribution of genetic factors. Nonetheless, only a few genes have been identified to date. We aimed to identify genetic variants associated with asthma exacerbations despite ICS use in European children and young adults and to validate the findings in non-Europeans. Moreover, we explored whether a gene-set enrichment analysis could suggest potential novel asthma therapies.

Methods

A genome-wide association study (GWAS) of asthma exacerbations was tested in 2681 children of European descent treated with ICS from eight studies. Suggestive association signals were followed up for replication in 538 European a

SUBMITTER: Hernandez-Pacheco N 

PROVIDER: S-EPMC8122045 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature