Sex differences in the IntelliCage and the Morris water maze in the APP/PS1 mouse model of amyloidosis.

ABSTRACT: Transgenic rodent models were created to decipher pathogenic mechanisms associated with Alzheimer's disease (AD), and behavioral apparatuses such as the Morris water maze (MWM) are used to assess cognition in mice. The IntelliCage was designed to circumvent issues of traditional behavioral tests, such as frequent human handling. The motivation to complete IntelliCage tasks is water consumption, which is less stressful than escaping from a pool in the MWM. Here, we examined behavioral performances of mice in the IntelliCage and MWM tasks. Twelve-month-old male and female APP/PS1 and non-transgenic mice first underwent 42 days of IntelliCage testing to assess prefrontal cortical and hippocampal function followed by MWM testing for six days. We found that females performed better in the Intel

SUBMITTER: Mifflin MA 

PROVIDER: S-EPMC8122060 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature