Cell-programmed nutrient partitioning in the tumour microenvironment.

ABSTRACT: Cancer cells characteristically consume glucose through Warburg metabolism¹, a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metabolism in the tumour microenvironment (TME) contributes to immune evasion by tumour cells^2-4. However, whether the metabolism of immune cells is dysregulated in the TME by cell-intrinsic programs or by competition with cancer cells for limited nutrients remains unclear. Here we used PET tracers to measure the access to and uptake of glucose and glutamine by specific cell subsets in the TME. Notably, myeloid cells had the greatest capacity to take up intratumoral glucose, followed by T cells and cancer cells, across a range

SUBMITTER: Reinfeld BI 

PROVIDER: S-EPMC8122068 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature