Ontology highlight
ABSTRACT:
SUBMITTER: Reinfeld BI
PROVIDER: S-EPMC8122068 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Reinfeld Bradley I BI Madden Matthew Z MZ Wolf Melissa M MM Chytil Anna A Bader Jackie E JE Patterson Andrew R AR Sugiura Ayaka A Cohen Allison S AS Ali Ahmed A Do Brian T BT Muir Alexander A Lewis Caroline A CA Hongo Rachel A RA Young Kirsten L KL Brown Rachel E RE Todd Vera M VM Huffstater Tessa T Abraham Abin A O'Neil Richard T RT Wilson Matthew H MH Xin Fuxue F Tantawy M Noor MN Merryman W David WD Johnson Rachelle W RW Williams Christopher S CS Mason Emily F EF Mason Frank M FM Beckermann Katherine E KE Vander Heiden Matthew G MG Manning H Charles HC Rathmell Jeffrey C JC Rathmell W Kimryn WK
Nature 20210407 7858
Cancer cells characteristically consume glucose through Warburg metabolism<sup>1</sup>, a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metabolism in the tumour microenvironment (TME) contributes to immune evasion by tumour cells<sup>2-4</sup>. However, whether the metabolism of immune cells is dysregulated in the TME by cell-intrinsic programs or by competition with cancer cel ...[more]