Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis.

ABSTRACT:

Background

The relationship between tuberculosis (TB), one of the leading infectious causes of death worldwide, and the microbiome, which is critical for health, is poorly understood.

Methods

To identify potential microbiome-host interactions, profiling of the oral, sputum and stool microbiota [n = 58 cases, n = 47 culture-negative symptomatic controls (SCs)] and whole blood transcriptome were done in pre-treatment presumptive pulmonary TB patients. This was a cross-sectional study. Microbiota were also characterised in close contacts of cases (CCCs, n = 73) and close contacts of SCs (CCSCs, n = 82) without active TB.

Findings

Cases and SCs each had similar α- and β-diversities in oral washes and sputum, however, β-diversity differed in stool (PERMANOVA p = 0•035). Ca

SUBMITTER: Naidoo CC 

PROVIDER: S-EPMC8122180 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature