Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small RNA molecules that modulate post-transcriptional gene regulation. They are often used as promising non-invasive biomarkers for the early diagnosis of cancer. However, their roles in assisted reproduction are still unknown.

Methods

This prospective study was designed to evaluate the expression profiles of seven extracellular miRNAs (miR-7-5p, miR-202-5p, miR-378-3p, miR-224, miR-320a, miR-212-3p, and miR-21-5p) in human follicular fluid (FF) to explore the outcomes of in vitro fertilization (IVF). Of 255 women, 145 were without polycystic ovary syndrome (PCOS), and their ovarian assets were normal (NOR), while 110 were with normo-androgenic PCOS.

Results

The combination of six FF miRNAs expression profile discriminated between PC

SUBMITTER: Khan HL 

PROVIDER: S-EPMC8122550 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature