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Polyphenolic Profile of Callistemon viminalis Aerial Parts: Antioxidant, Anticancer and In Silico 5-LOX Inhibitory Evaluations.


ABSTRACT: Five new compounds viz kaempferol 3-O-(4″-galloyl)-β-d-glucopyranosyl-(1‴→6″)-O-β-d-glucopyranoside (1), kaempferol 3-O-β-d-mannuronopyranoside (2), kaempferol 3-O-β-d-mannopyranoside (3), quercetin 3-O-β-d-mannuronopyranoside (4), 2, 3 (S)- hexahydroxydiphenoyl]-d-glucose (5) along with fifteen known compounds were isolated from 80% aqueous methanol extract (AME) of C. viminalis. AME and compounds exerted similar or better antioxidant activity to ascorbic acid using DPPH, O2-, and NO inhibition methods. In addition, compounds 16, 4, and 7 showed cytotoxic activity against MCF-7 cell lines while 3, 7 and 16 exhibited strong activity against HepG2. An in silico analysis using molecular docking for polyphenolic compounds 2, 3, 7, 16 and 17 against human stable 5-LOX was performed and compared to that of ascorbic acid and quercetin. The binding mode as well as the enzyme-inhibitor interactions were evaluated. All compounds occupied the 5-LOX active site and showed binding affinity greater than ascorbic acid or quercetin. The data herein suggest that AME, a source of polyphenols, could be used against oxidative-stress-related disorders.

SUBMITTER: Mahgoub S 

PROVIDER: S-EPMC8123052 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Polyphenolic Profile of <i>Callistemon viminalis</i> Aerial Parts: Antioxidant, Anticancer and In Silico 5-LOX Inhibitory Evaluations.

Mahgoub Shahenda S   Hashad Nashwa N   Ali Sahar S   Ibrahim Reham R   Said Ahmed M AM   Moharram Fatma A FA   Mady Mohamed M  

Molecules (Basel, Switzerland) 20210424 9


Five new compounds <i>viz</i> kaempferol 3-<i>O</i>-(4″-galloyl)-<i>β</i>-d-glucopyranosyl-(1‴→6″)-<i>O</i>-β-d-glucopyranoside (<b>1</b>), kaempferol 3-<i>O</i>-<i>β</i>-d-mannuronopyranoside (<b>2</b>), kaempferol 3-<i>O</i>-<i>β</i>-d-mannopyranoside (<b>3</b>), quercetin 3-<i>O</i>-<i>β</i>-d-mannuronopyranoside (<b>4</b>), 2, 3 (S)- hexahydroxydiphenoyl]-d-glucose (<b>5</b>) along with fifteen known compounds were isolated from 80% aqueous methanol extract (AME) of <i>C. viminalis</i>. AME  ...[more]

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