AS-Quant: Detection and Visualization of Alternative Splicing Events with RNA-seq Data.

ABSTRACT: (1) Background: A simplistic understanding of the central dogma falls short in correlating the number of genes in the genome to the number of proteins in the proteome. Post-transcriptional alternative splicing contributes to the complexity of the proteome and is critical in understanding gene expression. mRNA-sequencing (RNA-seq) has been widely used to study the transcriptome and provides opportunity to detect alternative splicing events among different biological conditions. Despite the popularity of studying transcriptome variants with RNA-seq, few efficient and user-friendly bioinformatics tools have been developed for the genome-wide detection and visualization of alternative splicing events. (2) Results: We propose AS-Quant, (Alternative Splicing Quantitation), a robust program to id

SUBMITTER: Fahmi NA 

PROVIDER: S-EPMC8123109 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature