Differentially expressed genes, lncRNAs, and competing endogenous RNAs in Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease (KD) is an acute and febrile systemic vasculitis of unknown etiology. This study aimed to identify the competing endogenous RNA (ceRNA) networks of lncRNAs, miRNAs, and genes in KD and explore the molecular mechanisms underlying KD.

Methods

GSE68004 and GSE73464 datasets were downloaded from the Gene Expression Omnibus. Differentially expressed lncRNAs (DElncRNAs) and genes (DEGs) in KD were identified using the criteria of p < 0.05 and | log₂ (fold change) | ≥ 1. MicroRNAs (miRNAs) related to KD were searched from databases. The lncRNA-miRNA-mRNA networks involving the DElncRNAs and DEGs were constructed.

Results

A total of 769 common upregulated, 406 common downregulated DEGs, and six DElncRNAs were identified in the KD

SUBMITTER: Guo C 

PROVIDER: S-EPMC8123229 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature