Prediction of Tumor Cellularity in Resectable PDAC from Preoperative Computed Tomography Imaging.

ABSTRACT: PDAC remains a tumor entity with poor prognosis and a 5-year survival rate below 10%. Recent research has revealed invasive biomarkers, such as distinct molecular subtypes, predictive for therapy response and patient survival. Non-invasive prediction of individual patient outcome however remains an unresolved task. Discrete cellularity regions of PDAC resection specimen (n = 43) were analyzed by routine histopathological work up. Regional tumor cellularity and CT-derived Hounsfield Units (HU, n = 66) as well as iodine concentrations were regionally matched. One-way ANOVA and pairwise t-tests were performed to assess the relationship between different cellularity level in conventional, virtual monoenergetic 40 keV (monoE 40 keV) and iodine map reconstructions. A statistically significant ne

SUBMITTER: Jungmann F 

PROVIDER: S-EPMC8123300 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature