A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.

ABSTRACT: Transcranial magnetic stimulation (TMS) is a noninvasive method to stimulate the cerebral cortex that has applications in psychiatry, such as in the treatment of depression and anxiety. Although many TMS targeting methods that use figure-8 coils exist, many do not account for individual differences in anatomy or are not generalizable across target sites. This protocol combines functional magnetic resonance imaging (fMRI) and iterative electric-field (E-field) modeling in a generalized approach to subject-specific TMS targeting that is capable of optimizing the stimulation site and TMS coil orientation. To apply this protocol, the user should (i) operationally define a region of interest (ROI), (ii) generate the head model from the structural MRI data, (iii) preprocess the functional MRI da

SUBMITTER: Balderston NL 

PROVIDER: S-EPMC8123368 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature