The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development.

ABSTRACT: In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000 people died. Moreover, men are 4 times more likely than women to be diagnosed with BC. The risk factors include exposure to environmental and occupational chemicals, especially tobacco smoke, benzidine and genetic factors. Despite numerous studies, the molecular basis of BC development remains unclear. A growing body of evidence suggests that inflammation, oxidant-antioxidant imbalance and angiogenesis disorders may play a significant role in the development and progression of bladder cancer. The patients with bladder cancer were characterised by an increased level of reactive oxygen species (ROS), the products of lipid peroxidation, proinflammatory cytokines and proangiogenic factors as compared to co

SUBMITTER: Wigner P 

PROVIDER: S-EPMC8123426 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature