De-Escalation of Therapy for Patients with Early-Stage Squamous Cell Carcinoma of the Anus.

ABSTRACT: The incidence of squamous cell carcinoma of the anus (SCCA) is increasing, particularly in the elderly, with increased mortality in this age group. While the current standard of care for localized SCCA remains chemoradiation (CRT), completion of this treatment can be challenging with risks for severe acute and late toxicity. It remains unclear if full course CRT is required for the management of early-stage SCCA or if de-escalation of treatment is possible without compromising patient outcomes. Alternative therapies include radiation therapy alone or local excision for appropriate patients. Modifying standard CRT may also reduce toxicity including the routine use of intensity-modulated radiation therapy for treatment delivery, modification of treatment volumes, and selection and dosing of

SUBMITTER: Miller E 

PROVIDER: S-EPMC8123637 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature