IPSCs: A Preclinical Drug Research Tool for Neurological Disorders.

ABSTRACT: The development and commercialization of new drugs is an articulated, lengthy, and very expensive process that proceeds through several steps, starting from target identification, screening new leading compounds for testing in preclinical studies, and subsequently in clinical trials to reach the final approval for therapeutic use. Preclinical studies are usually performed using both cell cultures and animal models, although they do not completely resume the complexity of human diseases, in particular neurodegenerative conditions. To this regard, stem cells represent a powerful tool in all steps of drug discovery. The recent advancement in induced Pluripotent Stem Cells (iPSCs) technology has opened the possibility to obtain patient-specific disease models for drug screening and development

SUBMITTER: Bonaventura G 

PROVIDER: S-EPMC8123805 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature