Genomic Correlates of DNA Damage in Breast Cancer Subtypes.

ABSTRACT: Among the described druggable vulnerabilities, acting on the DNA repair mechanism has gained momentum, with the approval of PARP inhibitors in several indications, including breast cancer. However, beyond the mere presence of BRCA1/BRCA2 mutations, the identification of additional biomarkers that would help to select tumors with an extreme dependence on DNA repair machinery would help to stratify therapeutic decisions. Gene set enrichment analyses (GSEA) using public datasets evaluating expression values between normal breast tissue and breast cancer identified a set of upregulated genes. Genes included in different pathways, such as ATM/ATR, BARD1, and Fanconi Anemia, which are involved in the DNA damage response, were selected and confirmed using molecular alteration

SUBMITTER: Cabanas Morafraile E 

PROVIDER: S-EPMC8123819 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature