Immuno-PET Molecular Imaging of RANKL in Cancer.

ABSTRACT:

Purpose

The involvement of RANK/RANKL signaling in the tumor microenvironment (TME) in driving response or resistance to immunotherapy has only very recently been recognized. Current quantification methods of RANKL expression suffer from issues such as sensitivity, variability, and uncertainty on the spatial heterogeneity within the TME, resulting in conflicting reports on its reliability and limited use in clinical practice. Non-invasive molecular imaging using immuno-PET is a promising approach combining superior targeting specificity of monoclonal antibodies (mAb) and spatial, temporal and functional information of PET. Here, we evaluated radiolabeled anti-RANKL mAbs as a non-invasive biomarker of RANKL expression in the TME.

Experimental design

Anti-human RANKL mAbs (AMG

SUBMITTER: Dewulf J 

PROVIDER: S-EPMC8124205 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature