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Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382".
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ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC8124425 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer <i>Cancers</i> 2020, <i>12</i>, 1382".
Cancers 20210507 9
In the Cancers paper, we observed the increase ALDH1L1 protein expression following oncogenesis, as well as a therapeutic effect, by deleting the <i>Aldh1l1</i> gene in <i>Kras<sup>LA2</sup></i> mice, a model of spontaneous non-small cell lung cancer (NSCLC) [...]. ...[more]