Ontology highlight
ABSTRACT:
SUBMITTER: Park DJ
PROVIDER: S-EPMC8124544 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Park Dong-Jun DJ Sung Pil-Soo PS Lee Gil-Won GW Cho Sungwoo S Kim Sung-Min SM Kang Byung-Yoon BY Hur Wonhee W Yang Hyun H Lee Soon-Kyu SK Lee Sung-Hak SH Jung Eun-Sun ES Seo Chang-Ho CH Ahn Joseph J Choi Ho-Joong HJ You Young-Kyoung YK Jang Jeong-Won JW Bae Si-Hyun SH Choi Jong-Young JY Yoon Seung-Kew SK
International journal of molecular sciences 20210429 9
A predictive biomarker of immune checkpoint inhibitor (ICI)-based treatments in hepatocellular carcinoma (HCC) has not been clearly demonstrated. In this study, we focused on the infiltration and programmed death ligand 1 (PD-L1) expression of tumor-associated macrophages (TAMs) in the tumor microenvironment of HCC. Immunohistochemistry demonstrated that PD-L1 was preferentially expressed on CD68<sup>+</sup> macrophages in the tumor microenvironment of HCC, suggestive of its expression in TAMs r ...[more]