Bidirectional links between adolescent brain function and substance use moderated by cognitive control.

ABSTRACT:

Background

No clear consensus exists as to whether neurodevelopmental abnormalities among substance users reflect predisposing neural risk factors, neurotoxic effects of substances, or both. Using a longitudinal design, we examined developmental patterns of the bidirectional links between neural mechanisms and substance use throughout adolescence.

Method

167 adolescents (aged 13-14 years at Time 1, 53% male) were assessed annually four times. Risk-related neural processing was assessed by blood-oxygen-level-dependent responses in the insula during a lottery choice task, cognitive control by behavioral performance during the Multi-Source Interference Task, and substance use by adolescents' self-reported cigarette, alcohol, and marijuana use.

Results

Latent change score

SUBMITTER: Kim-Spoon J 

PROVIDER: S-EPMC8124751 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature