Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration.

ABSTRACT: Glaucoma is a multifactorial disease that is conventionally managed with treatments to lower intraocular pressure (IOP). Despite these efforts, many patients continue to lose their vision. The degeneration of retinal ganglion cells (RGCs) and their axons in the optic tract that characterizes glaucoma is similar to neurodegeneration in other age-related disorders of the central nervous system (CNS). Identifying the different molecular signaling pathways that contribute to early neuronal dysfunction can be utilized for neuroprotective strategies that prevent degeneration. The discovery of insulin and its receptor in the CNS and retina led to exploration of the role of insulin signaling in the CNS. Historically, insulin was considered a peripherally secreted hormone that regulated glucose hom

SUBMITTER: Al Hussein Al Awamlh S 

PROVIDER: S-EPMC8124776 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature