Lumican Inhibits Osteoclastogenesis and Bone Resorption by Suppressing Akt Activity.

ABSTRACT: Lumican, a ubiquitously expressed small leucine-rich proteoglycan, has been utilized in diverse biological functions. Recent experiments demonstrated that lumican stimulates preosteoblast viability and differentiation, leading to bone formation. To further understand the role of lumican in bone metabolism, we investigated its effects on osteoclast biology. Lumican inhibited both osteoclast differentiation and in vitro bone resorption in a dose-dependent manner. Consistent with this, lumican markedly decreased the expression of osteoclastogenesis markers. Moreover, the migration and fusion of preosteoclasts and the resorptive activity per osteoclast were significantly reduced in the presence of lumican, indicating that this protein affects most stages of osteoclastogenesis. Among RANKL-depe

SUBMITTER: Lee JY 

PROVIDER: S-EPMC8124849 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature