Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression.
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ABSTRACT:
SUBMITTER: Panajatovic MV
PROVIDER: S-EPMC8125015 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression.
Panajatovic Miljenko V MV Singh Francois F Krähenbühl Stephan S Bouitbir Jamal J
International journal of molecular sciences 20210507 9
Previous studies suggest that statins may disturb skeletal muscle lipid metabolism potentially causing lipotoxicity with insulin resistance. We investigated this possibility in wild-type mice (WT) and mice with skeletal muscle PGC-1α overexpression (PGC-1α OE mice). In WT mice, simvastatin had only minor effects on skeletal muscle lipid metabolism but reduced glucose uptake, indicating impaired insulin sensitivity. Muscle PGC-1α overexpression caused lipid droplet accumulation in skeletal muscle ...[more]
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