Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology.

ABSTRACT: Although osteoarthritis (OA) is the most common musculoskeletal condition that causes significant health and social problems worldwide, its exact etiology is still unclear. With an aging and increasingly obese population, OA is becoming even more prevalent than in previous decades. Up to 35% of the world's population over 60 years of age suffers from symptomatic (painful, disabling) OA. The disease poses a tremendous economic burden on the health-care system and society for diagnosis, treatment, sick leave, rehabilitation, and early retirement. Most patients also experience sleep disturbances, reduced capability for exercising, lifting, and walking and are less capable of working, and maintaining an independent lifestyle. For patients, the major problem is disability, resulting from joint

SUBMITTER: Grassel S 

PROVIDER: S-EPMC8125020 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature