Genetics of Familial Non-Medullary Thyroid Carcinoma (FNMTC).

ABSTRACT: Non-medullary thyroid carcinoma (NMTC) is the most frequent endocrine tumor and originates from the follicular epithelial cells of the thyroid. Familial NMTC (FNMTC) has been defined in pedigrees where two or more first-degree relatives of the patient present the disease in absence of other predisposing environmental factors. Compared to sporadic cases, FNMTCs are often multifocal, recurring more frequently and showing an early age at onset with a worse outcome. FNMTC cases show a high degree of genetic heterogeneity, thus impairing the identification of the underlying molecular causes. Over the last two decades, many efforts in identifying the susceptibility genes in large pedigrees were carried out using linkage-based approaches and genome-wide association studies, leading to the identif

SUBMITTER: Diquigiovanni C 

PROVIDER: S-EPMC8125431 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature