Genetically Modified Ferritin Nanoparticles with Bone-Targeting Peptides for Bone Imaging.

ABSTRACT: Bone homeostasis plays a major role in supporting and protecting various organs as well as a body structure by maintaining the balance of activities of the osteoblasts and osteoclasts. Unbalanced differentiation and functions of these cells result in various skeletal diseases, such as osteoporosis, osteopetrosis, and Paget's disease. Although various synthetic nanomaterials have been developed for bone imaging and therapy through the chemical conjugation, they are associated with serious drawbacks, including heterogeneity and random orientation, in turn resulting in low efficiency. Here, we report the synthesis of bone-targeting ferritin nanoparticles for bone imaging. Ferritin, which is a globular protein composed of 24 subunits, was employed as a carrier molecule. Bone-targeting peptides

SUBMITTER: Kim JW 

PROVIDER: S-EPMC8125493 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature