Identification of New Potential Inhibitors of Quorum Sensing through a Specialized Multi-Level Computational Approach.

ABSTRACT: Biofilms are aggregates of microorganisms anchored to a surface and embedded in a self-produced matrix of extracellular polymeric substances and have been associated with 80% of all bacterial infections in humans. Because bacteria in biofilms are less amenable to antibiotic treatment, biofilms have been associated with developing antibiotic resistance, a problem that urges developing new therapeutic options and approaches. Interfering with quorum-sensing (QS), an important process of cell-to-cell communication by bacteria in biofilms is a promising strategy to inhibit biofilm formation and development. Here we describe and apply an in silico computational protocol for identifying novel potential inhibitors of quorum-sensing, using CviR-the quorum-sensing receptor from Chromobacterium vi

SUBMITTER: Martins FG 

PROVIDER: S-EPMC8125606 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature